Compound Detail
CHEMBL4797682
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Basic Information
| ChEMBL ID | CHEMBL4797682 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ITNKBNSWICSPJS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.5
MW (Da)
1.89
ALogP
8
HBA
2
HBD
101.4
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | IC50 | 6.34 | 6.34 | 454.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | IC50 | = | 454.0 | nM | 6.34 | Inhibition of recombinant human N-terminal GST-tagged MNK2 (1 to 465 residues) e... | 30824167 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30824167 | 10.1016/j.bmc.2019.02.007 | MAP kinase-interacting serine/threonine-protein kinase 2 | 2 |
| 30824167 | 10.1016/j.bmc.2019.02.007 | MAP kinase-interacting serine/threonine-protein kinase 1 | 2 |
Data from ChEMBL 36 via Core Engine