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Compound Detail

CHEMBL4799655

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COc1cccc(-c2csc(Nc3ccccc3F)n2)c1

Basic Information

ChEMBL ID CHEMBL4799655
Phase Preclinical
Structure Type MOL
InChI Key FDMWJUYVXTWLFG-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

300.4
MW (Da)
4.70
ALogP
4
HBA
1
HBD
34.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H13FN2OS
MW 300.36
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -2.14

Activity Summary

EC50 1 meas. best 5.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.69 5.69 2050.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 0.1367 hr Homo sapiens
T1/2 0.06333 hr Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 2050.0 nM 5.69 Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfect... 33139114

Literature References

PubMed DOI Target Context # Activities
33139114 10.1016/j.ejmech.2020.112952 Unchecked 2
33139114 10.1016/j.ejmech.2020.112952 ADMET 2
33139114 10.1016/j.ejmech.2020.112952 No relevant target 1

Data from ChEMBL 36 via Core Engine