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Compound Detail

CHEMBL482098

XANTHOKEISMINS B
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CC(C)(O)/C=C/CC(C)(O)[C@H]1Oc2ccc(C(=O)/C=C/c3ccc(O)cc3)c(O)c2[C@@H]1O

Basic Information

ChEMBL ID CHEMBL482098
Name XANTHOKEISMINS B
Phase Preclinical
Structure Type MOL
InChI Key SWONFSQDRVSFHS-VIUSQTLFSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

440.5
MW (Da)
3.26
ALogP
7
HBA
5
HBD
127.5
PSA (Ų)
0.25
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C25H28O7
MW 440.49
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness 1.94

Activity Summary

IC50 1 meas. best 6.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.16 6.16 690.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 690.0 nM 6.16 Superoxide-scavenging activity assessed as inhibition of formation of WST1 forma... 18558745

Literature References

PubMed DOI Target Context # Activities
18558745 10.1021/np800187f Unchecked 1

Data from ChEMBL 36 via Core Engine