Compound Detail
CHEMBL483934
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Basic Information
| ChEMBL ID | CHEMBL483934 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TZGGJKMAPZGDSV-CYBMUJFWSA-N |
1
Targets
2
Activities
1
Assay Types
5
PK Parameters
5
Publications
0
Known Names
Molecular Properties
383.4
MW (Da)
3.09
ALogP
5
HBA
3
HBD
104.5
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.58 | 7.02 | 26.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 6.4 | microM/hr/mg | Mus musculus |
| CL | 3.52 | mL.min-1.kg-1 | Mus musculus |
| Cmax | 4780.0 | nM | Mus musculus |
| F | 52.0 | % | Mus musculus |
| T1/2 | 4.8 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 26.0 | nM | 7.58 | Displacement of [3H]Niacin from human niacin receptor expressed in CHO cells | 18477506 |
| Unchecked | IC50 | = | 350.0 | nM | 6.46 | Agonist activity at human niacin receptor expressed in CHO cells by GTPgammaS bi... | 18477506 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18477506 | 10.1016/j.bmcl.2008.04.071 | Mus musculus | 6 |
| 18477506 | 10.1016/j.bmcl.2008.04.071 | Unchecked | 2 |
| 18477506 | 10.1016/j.bmcl.2008.04.071 | No relevant target | 2 |
| 18477506 | 10.1016/j.bmcl.2008.04.071 | Cytochrome P450 2C8 | 1 |
| 18477506 | 10.1016/j.bmcl.2008.04.071 | Cytochrome P450 2C9 | 1 |
Data from ChEMBL 36 via Core Engine