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Compound Detail

CHEMBL4848279

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N#Cc1cncc(COc2cc(OC3CCc4c(-c5ccccc5)cccc43)c(Cl)cc2CN[C@@H](CO)C(=O)O)c1

Basic Information

ChEMBL ID CHEMBL4848279
Phase Preclinical
Structure Type MOL
InChI Key XFMADIVPJSLSMQ-XLTVJXRZSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

570.0
MW (Da)
5.45
ALogP
7
HBA
3
HBD
124.7
PSA (Ų)
0.22
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H28ClN3O5
MW 570.05
Aromatic Rings 4
Heavy Atoms 41
NP-Likeness -0.35

Literature References

PubMed DOI Target Context # Activities
33770574 10.1016/j.ejmech.2021.113377 Programmed cell death 1 ligand 1 1
34610423 10.1016/j.bmcl.2021.128403 Programmed cell death protein 1/Programmed cell death 1 ligand 1 1
33773287 10.1016/j.ejmech.2021.113356 Programmed cell death 1 ligand 1 1

Data from ChEMBL 36 via Core Engine