Compound Detail
CHEMBL4853612
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Basic Information
| ChEMBL ID | CHEMBL4853612 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IGQCCPXSHBTJOW-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
491.9
MW (Da)
5.56
ALogP
7
HBA
2
HBD
69.2
PSA (Ų)
0.45
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 1 CHEMBL2252 | IC50 | 7.12 | 7.0367 | 75.5 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 1 | IC50 | = | 75.5 | nM | 7.12 | Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as subs... | 34374541 |
| Dipeptidyl peptidase 1 | IC50 | = | 92.0 | nM | 7.04 | Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pre... | 34374541 |
| Dipeptidyl peptidase 1 | IC50 | = | 112.0 | nM | 6.95 | Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as subs... | 34374541 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34374541 | 10.1021/acs.jmedchem.1c00104 | Dipeptidyl peptidase 1 | 3 |
| 34374541 | 10.1021/acs.jmedchem.1c00104 | L02 | 1 |
Data from ChEMBL 36 via Core Engine