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Compound Detail

CHEMBL4856076

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COc1ccc(C(OC[C@H]2O[C@@H](n3cc4c(nc3=O)Nc3ccccc3O4)[C@H](O)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

Basic Information

ChEMBL ID CHEMBL4856076
Phase Preclinical
Structure Type MOL
InChI Key GINDXSVNPBZSCC-UKNNOAMWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

635.7
MW (Da)
4.74
ALogP
11
HBA
3
HBD
133.5
PSA (Ų)
0.19
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H33N3O8
MW 635.67
Aromatic Rings 5
Heavy Atoms 47
NP-Likeness 0.27

Activity Summary

EC50 1 meas. best 4.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
SARS-CoV-2
CHEMBL4303835
EC50 4.94 4.94 11500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
SARS-CoV-2 EC50 = 11500.0 nM 4.94 Antiviral activity against SARS COV-2 infected in monkey vero cells assessed as ... 33894564

Literature References

PubMed DOI Target Context # Activities
33894564 10.1016/j.ejmech.2021.113467 Vero 1
33894564 10.1016/j.ejmech.2021.113467 SARS-CoV-2 1

Data from ChEMBL 36 via Core Engine