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Compound Detail

CHEMBL4856628

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Cc1ccc2c(c1)N=C(C1=CCNCC1)c1cc(F)ccc1N2

Basic Information

ChEMBL ID CHEMBL4856628
Phase Preclinical
Structure Type MOL
InChI Key NZTNTJJXYHMEGN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

307.4
MW (Da)
4.23
ALogP
3
HBA
2
HBD
36.4
PSA (Ų)
0.83
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H18FN3
MW 307.37
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.34

Activity Summary

Ki 1 meas. best 6.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
Ki 6.07 6.07 848.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33691168 10.1016/j.bmcl.2021.127911 Muscarinic acetylcholine receptor M1 2
33691168 10.1016/j.bmcl.2021.127911 Muscarinic acetylcholine receptor M2 1
33691168 10.1016/j.bmcl.2021.127911 Muscarinic acetylcholine receptor M3 1
33691168 10.1016/j.bmcl.2021.127911 Muscarinic acetylcholine receptor M4 1
33691168 10.1016/j.bmcl.2021.127911 D(2) dopamine receptor 1
33691168 10.1016/j.bmcl.2021.127911 ADMET 1

Data from ChEMBL 36 via Core Engine