Compound Detail
CHEMBL4858548
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Basic Information
| ChEMBL ID | CHEMBL4858548 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GWCQBRMBTHMFHB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
289.8
MW (Da)
3.06
ALogP
4
HBA
1
HBD
46.9
PSA (Ų)
0.92
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleosome-remodeling factor subunit BPTF CHEMBL3085621 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleosome-remodeling factor subunit BPTF | IC50 | = | 3900.0 | nM | 5.41 | Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL... | 34515477 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34515477 | 10.1021/acs.jmedchem.1c01294 | Nucleosome-remodeling factor subunit BPTF | 1 |
Data from ChEMBL 36 via Core Engine