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Compound Detail

CHEMBL485998

FRIEDELINE
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C[C@H]1C(=O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@@]2(C)CC[C@@]2(C)[C@@H]3CC(C)(C)CC[C@]3(C)CC[C@]12C

Basic Information

ChEMBL ID CHEMBL485998
Name FRIEDELINE
Phase Preclinical
Structure Type MOL
InChI Key OFMXGFHWLZPCFL-SVRPQWSVSA-N
0
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

426.7
MW (Da)
8.46
ALogP
1
HBA
0
HBD
17.1
PSA (Ų)
0.38
QED
1
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H50O
MW 426.73
Aromatic Rings 0
Heavy Atoms 31
NP-Likeness 2.64

Activity Summary

IC50 4 meas.
EC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
24559087 10.1021/np400323u HepG2 7
22578462 10.1016/j.bmcl.2012.04.081 Unchecked 3
19911773 10.1021/jm900872z G-protein coupled bile acid receptor 1 2
26508549 10.1016/j.bmcl.2015.10.034 Isocitrate dehydrogenase [NADP] cytoplasmic 2
29627260 10.1016/j.bmcl.2018.03.076 Unchecked 2
29353722 10.1016/j.ejmech.2018.01.011 HepG2 2
29627260 10.1016/j.bmcl.2018.03.076 Hepatitis B virus 2
- 10.1021/np50014a012 Phytophthora cactorum 1
18341288 10.1021/np800001v Unchecked 1
18926710 10.1016/j.bmc.2008.09.021 Unchecked 1
11678649 10.1021/np010217m NON-PROTEIN TARGET 1
19911773 10.1021/jm900872z Bile acid receptor 1
20153184 10.1016/j.bmcl.2010.01.096 HL-60 1
20153184 10.1016/j.bmcl.2010.01.096 SK-OV-3 1
20153184 10.1016/j.bmcl.2010.01.096 A549 1
11678649 10.1021/np010217m SF-268 1
20153184 10.1016/j.bmcl.2010.01.096 RAW264.7 1
11678649 10.1021/np010217m NCI-H460 1
23062825 10.1016/j.bmc.2012.09.040 Acetylcholinesterase 1
11678649 10.1021/np010217m UACC-62 1

Data from ChEMBL 36 via Core Engine