Compound Detail
CHEMBL4863142
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4863142 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIWMBCHTAJIGDG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
401.8
MW (Da)
5.02
ALogP
3
HBA
2
HBD
79.5
PSA (Ų)
0.64
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endoplasmic reticulum aminopeptidase 1 CHEMBL5939 | IC50 | 7.0 | 7.0 | 99.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endoplasmic reticulum aminopeptidase 1 | IC50 | = | 99.0 | nM | 7.0 | Inhibition of wild type ERAP1 (unknown origin) using L-Rho-Succ-FKARKF as substr... | 34267884 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34267884 | 10.1021/acsmedchemlett.1c00235 | Endoplasmic reticulum aminopeptidase 1 | 1 |
| 34267884 | 10.1021/acsmedchemlett.1c00235 | Endoplasmic reticulum aminopeptidase 2 | 1 |
| 34267884 | 10.1021/acsmedchemlett.1c00235 | Aminopeptidase N | 1 |
Data from ChEMBL 36 via Core Engine