Compound Detail
CHEMBL4864054
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Basic Information
| ChEMBL ID | CHEMBL4864054 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZECPXAKISSCITD-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
276.3
MW (Da)
2.76
ALogP
4
HBA
3
HBD
77.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | EC50 | 5.08 | 5.08 | 8300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 | EC50 | = | 8300.0 | nM | 5.08 | Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis... | 34374537 |
| Neuronal acetylcholine receptor subunit alpha-7 | EC50 | = | 8300.0 | nM | 5.08 | Positive allosteric modulation of human alpha7 nAChR expressed in xenopus laevis... | 38393821 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34374537 | 10.1021/acs.jmedchem.1c01058 | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
| 38393821 | 10.1021/acs.jmedchem.3c02323 | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
Data from ChEMBL 36 via Core Engine