Compound Detail
CHEMBL4864263
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Basic Information
| ChEMBL ID | CHEMBL4864263 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JLLYLYAWTGEXCF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
4.03
ALogP
4
HBA
1
HBD
72.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Retinoic acid receptor RXR-beta CHEMBL1870 | EC50 | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | EC50 | = | 1400.0 | nM | 5.85 | Agonist activity at human RXRalpha transfected in human HEK293T cells co-express... | 33793232 |
| Retinoic acid receptor RXR-beta | EC50 | = | 1800.0 | nM | 5.75 | Agonist activity at human RXRbeta transfected in human HEK293T cells co-expressi... | 33793232 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33793232 | 10.1021/acs.jmedchem.1c00235 | Retinoic acid receptor RXR-alpha | 2 |
| 33793232 | 10.1021/acs.jmedchem.1c00235 | Retinoic acid receptor RXR-beta | 2 |
| 33793232 | 10.1021/acs.jmedchem.1c00235 | Retinoic acid receptor RXR-gamma | 1 |
| 39081058 | 10.1021/acs.jmedchem.4c01218 | Nuclear receptor subfamily 4 group A member 2 | 1 |
| 39081058 | 10.1021/acs.jmedchem.4c01218 | Unchecked | 1 |
| 39081058 | 10.1021/acs.jmedchem.4c01218 | HEK-293T | 1 |
Data from ChEMBL 36 via Core Engine