Compound Detail
CHEMBL4865670
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Basic Information
| ChEMBL ID | CHEMBL4865670 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAMVPRDOVPKGPL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
318.4
MW (Da)
2.24
ALogP
4
HBA
4
HBD
118.4
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H2 receptor CHEMBL1941 | Ki | 5.28 | 5.28 | 5248.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H2 receptor | Ki | = | 5248.07 | nM | 5.28 | Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 i... | 33548637 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H2 receptor | 5 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H1 receptor | 1 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H3 receptor | 1 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Histamine H4 receptor | 1 |
| 33548637 | 10.1016/j.ejmech.2021.113190 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine