Compound Detail
CHEMBL4870121
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Basic Information
| ChEMBL ID | CHEMBL4870121 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KXADAXCTIOUNBQ-LLVKDONJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
280.3
MW (Da)
2.03
ALogP
6
HBA
0
HBD
59.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.83 | 6.83 | 147.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 147.91 | nM | 6.83 | Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expr... | 34342227 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | ADMET | 2 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | No relevant target | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity protein kinase CLK1 | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity protein kinase CLK2 | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Dual specificity protein kinase CLK3 | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Cyclin-dependent kinase 2 | 1 |
| 34342227 | 10.1021/acs.jmedchem.1c01115 | Glycogen synthase kinase-3 beta | 1 |
Data from ChEMBL 36 via Core Engine