Compound Detail
CHEMBL4871944
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Basic Information
| ChEMBL ID | CHEMBL4871944 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VBNHXUAHZPDQJV-AWEZNQCLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
390.5
MW (Da)
5.28
ALogP
5
HBA
3
HBD
78.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 6 CHEMBL6144 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| Aurora kinase A CHEMBL4722 | IC50 | 7.12 | 7.12 | 75.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G protein-coupled receptor kinase 6 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of recombinant full-length human GRK6 using casein as substrate measu... | 34291633 |
| Aurora kinase A | IC50 | = | 75.0 | nM | 7.12 | Inhibition of recombinant full length human Aurora A using LRRASLG as substrate ... | 34291633 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34291633 | 10.1021/acs.jmedchem.1c00506 | G protein-coupled receptor kinase 6 | 1 |
| 34291633 | 10.1021/acs.jmedchem.1c00506 | Aurora kinase A | 1 |
Data from ChEMBL 36 via Core Engine