Compound Detail
CHEMBL4874774
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Cc1ncnc2c1ccn2[C@@H]1O[C@@H]2[C@H](Cc3ccc4cc(Br)c(N)nc4c3)CC[C@]2(O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL4874774 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHFDOIQYYQBEKE-BNQFTCSMSA-N |
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
4
Publications
0
Known Names
Molecular Properties
510.4
MW (Da)
3.27
ALogP
8
HBA
3
HBD
119.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Z-138 CHEMBL4483276 | EC50 | 8.85 | 8.85 | 1.4 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 27.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 2163.0 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 46.0 | % | Rattus norvegicus |
| MRT | 1.1 | hr | Rattus norvegicus |
| Vd | 148.0 | L.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Z-138 | EC50 | = | 1.4 | nM | 8.85 | Antiproliferative activity against human Z138 cells incubated for 10 days by cel... | 33755451 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33755451 | 10.1021/acs.jmedchem.0c02083 | ADMET | 5 |
| 33755451 | 10.1021/acs.jmedchem.0c02083 | No relevant target | 3 |
| 33755451 | 10.1021/acs.jmedchem.0c02083 | Protein arginine N-methyltransferase 5 | 1 |
| 33755451 | 10.1021/acs.jmedchem.0c02083 | Z-138 | 1 |
Data from ChEMBL 36 via Core Engine