Compound Detail
CHEMBL4876736
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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(N)=O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL4876736 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ATMSTELHXVEGAU-HGUOCSJCSA-N |
2
Targets
3
Activities
1
Assay Types
3
PK Parameters
6
Publications
0
Known Names
Molecular Properties
2973.3
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon receptor CHEMBL1985 | IC50 | 8.05 | 7.985 | 9.0 | 2 |
| Glucagon receptor CHEMBL4773 | IC50 | 7.64 | 7.64 | 23.1 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 621.42 | ng.hr.mL-1 | Mus musculus |
| Cmax | 261.0 | nM | Mus musculus |
| T1/2 | 0.5117 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon receptor | IC50 | = | 9.0 | nM | 8.05 | Displacement of 125I-glucagon from human GCGR expressed in HEK293 cells membrane... | 33821647 |
| Glucagon receptor | IC50 | = | 12.1 | nM | 7.92 | Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibiti... | 33821647 |
| Glucagon receptor | IC50 | = | 23.1 | nM | 7.64 | Antagonist activity at mouse GCGR expressed in CHO-K1 cells assessed as inhibiti... | 33821647 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33821647 | 10.1021/acs.jmedchem.0c02069 | Glucagon receptor | 5 |
| 33821647 | 10.1021/acs.jmedchem.0c02069 | Gastric inhibitory polypeptide receptor | 4 |
| 33821647 | 10.1021/acs.jmedchem.0c02069 | Glucagon-like peptide 1 receptor | 4 |
| 33821647 | 10.1021/acs.jmedchem.0c02069 | ADMET | 4 |
| 33821647 | 10.1021/acs.jmedchem.0c02069 | No relevant target | 2 |
| 33821647 | 10.1021/acs.jmedchem.0c02069 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine