Compound Detail

CHEMBL4876838

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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CSCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(N)=O)[C@@H](C)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4876838
Phase	Preclinical
Structure Type	MOL
InChI Key	SGVGLGKCUCRMDZ-WJXOWKRISA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3017.4

MW (Da)

Drug Information

Molecule Type	Unknown
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C134H198N36O40S2
MW	3017.40

Activity Summary

IC50 2 meas. best 7.15

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucagon receptor CHEMBL1985	IC50	7.15	7.06	71.4	2

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucagon receptor	IC50	=	71.4	nM	7.15	Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibiti...	33821647
Glucagon receptor	IC50	=	107.3	nM	6.97	Displacement of 125I-glucagon from human GCGR expressed in HEK293 cells membrane...	33821647

Literature References

PubMed	DOI	Target Context	# Activities
33821647	10.1021/acs.jmedchem.0c02069	Glucagon receptor	2

Data from ChEMBL 36 via Core Engine