Compound Detail
CHEMBL4878572
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Basic Information
| ChEMBL ID | CHEMBL4878572 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAHDNGVWTGJEGV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
431.5
MW (Da)
5.20
ALogP
6
HBA
0
HBD
64.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 260.0 | nM | 6.58 | Inhibition of FLT3 (unknown origin) using 5' FAM-EPLYWSFPA peptide as a substrat... | 34479037 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34479037 | 10.1016/j.ejmech.2021.113776 | MOLM-14 | 27 |
| 34479037 | 10.1016/j.ejmech.2021.113776 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 34479037 | 10.1016/j.ejmech.2021.113776 | Serine/threonine-protein kinase Nek2 | 1 |
| 34479037 | 10.1016/j.ejmech.2021.113776 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine