Compound Detail
CHEMBL488576
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O=C([C@H]1O[C@@H](n2cnc3c(NC4CC4)nc(Cl)nc32)[C@H](O)[C@@H]1O)N1CCC(Cc2ccccc2)CC1
Basic Information
| ChEMBL ID | CHEMBL488576 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IXCCHWDEWMXLFU-CMCWBKRRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
513.0
MW (Da)
2.15
ALogP
9
HBA
3
HBD
125.6
PSA (Ų)
0.43
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A3 CHEMBL256 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A3 | Ki | = | 3981.07 | nM | 5.4 | Displacement of [125I]I-AB-MEAC from human adenosine A3 receptor expressed in CH... | 18973967 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18973967 | 10.1016/j.ejmech.2008.09.022 | Adenosine receptor A3 | 1 |
Data from ChEMBL 36 via Core Engine