Compound Detail
CHEMBL490357
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CC1(C)O[C@@H]2[C@H](O1)[C@@H](O[Si](C)(C)C(C)(C)C)C=C1c3cc4c(cc3C(=O)N[C@H]12)OCO4
Basic Information
| ChEMBL ID | CHEMBL490357 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XAHDDMCNCIYOSB-NMLBUPMWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
445.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | EC50 | 4.12 | 4.12 | 75000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | EC50 | = | 75000.0 | nM | 4.12 | Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells afte... | 23511018 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16441059 | 10.1021/np058068l | P388 | 1 |
| 23511018 | 10.1016/j.bmcl.2013.02.089 | Unchecked | 1 |
| 23511018 | 10.1016/j.bmcl.2013.02.089 | Hepatitis C virus | 1 |
| 23511018 | 10.1016/j.bmcl.2013.02.089 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine