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Compound Detail

CHEMBL492628

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N[C@@H](CCn1c2c(c(=O)n(CC[C@H](N)C(=O)O)c1=O)CCC2)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL492628
Phase Preclinical
Structure Type MOL
InChI Key RPYXYQHRAXAOCI-UWVGGRQHSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

354.4
MW (Da)
-1.90
ALogP
8
HBA
4
HBD
170.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H22N4O6
MW 354.36
Aromatic Rings 1
Heavy Atoms 25
NP-Likeness -0.24

Literature References

PubMed DOI Target Context # Activities
18811139 10.1021/jm800865a Glutamate receptor 1 1
18811139 10.1021/jm800865a Glutamate receptor 2 1
18811139 10.1021/jm800865a Glutamate receptor 3 1
18811139 10.1021/jm800865a Glutamate receptor 4 1
18811139 10.1021/jm800865a Glutamate receptor ionotropic, kainate 1 1
18811139 10.1021/jm800865a Glutamate receptor ionotropic, kainate 2 1

Data from ChEMBL 36 via Core Engine