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Compound Detail

CHEMBL493295

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CN(C)S(=O)(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL493295
Phase Preclinical
Structure Type MOL
InChI Key YEFIJEXZAWLRFG-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

441.5
MW (Da)
0.19
ALogP
7
HBA
3
HBD
133.6
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H24FN5O5S
MW 441.49
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -1.11

Activity Summary

IC50 1 meas. best 7.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus type 1 integrase
CHEMBL3471
 IC50 7.92 7.92 12.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Human immunodeficiency virus type 1 integrase IC50 = 12.0 nM 7.92 Inhibition of HIV1 recombinant integrase strand transfer activity 18763751

Literature References

PubMed DOI Target Context # Activities
18763751 10.1021/jm800245z Human immunodeficiency virus 1 2
18763751 10.1021/jm800245z Human immunodeficiency virus type 1 integrase 1

Data from ChEMBL 36 via Core Engine