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Compound Detail

CHEMBL497281

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O=C(O)COc1cccc(-c2ccc3c(c2)C[C@@H](NC[C@H](O)c2cccc(Cl)c2)CC3)c1

Basic Information

ChEMBL ID CHEMBL497281
Phase Preclinical
Structure Type MOL
InChI Key BAHMSWMBSNWHJY-ZCYQVOJMSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

451.9
MW (Da)
4.65
ALogP
4
HBA
3
HBD
78.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H26ClNO4
MW 451.95
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.67

Activity Summary

EC50 1 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.0 8.0 10.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18651730 10.1021/jm800222k Beta-3 adrenergic receptor 2
18651730 10.1021/jm800222k Canis familiaris 2
18651730 10.1021/jm800222k Unchecked 1
18651730 10.1021/jm800222k Beta-1 adrenergic receptor 1
18651730 10.1021/jm800222k Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine