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Compound Detail

CHEMBL498229

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Nc1ccc(Nc2cc(S(=O)(=O)[O-])c(N)c3c2C(=O)c2ccccc2C3=O)c(S(=O)(=O)[O-])c1.[Na+].[Na+]

Basic Information

ChEMBL ID CHEMBL498229
Phase Preclinical
Structure Type MOL
InChI Key WCAVPXPSGHGFCU-UHFFFAOYSA-L
Parent Compound CHEMBL1208117
Active Moiety CHEMBL1208117
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

489.5
MW (Da)
1.86
ALogP
9
HBA
5
HBD
206.9
PSA (Ų)
0.21
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H13N3Na2O8S2
MW 533.45
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.17

Activity Summary

Ki 1 meas. best 4.71

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 12
CHEMBL2001
Ki 4.71 4.71 19740.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
P2Y purinoceptor 12 Ki = 19740.0 nM 4.71 Displacement of [3H]PSB0413 from human platelet P2Y12 receptor 19463000

Literature References

PubMed DOI Target Context # Activities
19463000 10.1021/jm9003297 P2Y purinoceptor 12 1

Data from ChEMBL 36 via Core Engine