Compound Detail

CHEMBL499370

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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)C(C)C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL499370
Phase	Preclinical
Structure Type	BOTH
InChI Key	SNUALFGPRGVVPK-CCGBATFTSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3368.8

MW (Da)

Drug Information

Molecule Type	Protein
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C152H231N41O46
MW	3368.76

Activity Summary

EC50 1 meas. best 10.57

IC50 1 meas. best 8.54

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Glucagon-like peptide 1 receptor CHEMBL1784	EC50	10.57	10.57	0.0	1
Glucagon-like peptide 1 receptor CHEMBL1784	IC50	8.54	8.54	2.9	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Glucagon-like peptide 1 receptor	EC50	=	0.027	nM	10.57	Agonist activity at human GLP1R expressed in CHO cells assessed as increase in c...	18412318
Glucagon-like peptide 1 receptor	IC50	=	2.9	nM	8.54	Displacement of [125I]GLP1 from human GLP1R expressed in CHOK1 cells	18412318

Literature References

PubMed	DOI	Target Context	# Activities
18412318	10.1021/jm701522b	Glucagon-like peptide 1 receptor	2
18412318	10.1021/jm701522b	Plasma	1

Data from ChEMBL 36 via Core Engine