Compound Detail
CHEMBL501259
ERITORAN 🧪 Phase III
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🧪 Phase III
CCCCCC/C=C\CCCCCCCCCC(=O)N[C@H]1[C@H](OC[C@H]2O[C@H](OP(=O)(O)O)[C@H](NC(=O)CC(=O)CCCCCCCCCCC)[C@@H](OCCCCCCCCCC)[C@@H]2O)O[C@H](COC)[C@@H](OP(=O)(O)O)[C@@H]1OCC[C@@H](CCCCCCC)OC
Basic Information
| ChEMBL ID | CHEMBL501259 |
| Name | ERITORAN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | BPSMYQFMCXXNPC-MFCPCZTFSA-N |
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
2
Publications
1
Known Names
4
Indications
Molecular Properties
1313.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Influenza, Human Pneumonia Severe Acute Respiratory Syndrome Insulin Resistance
Activity Summary
IC50 1 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Toll-like receptor 4 CHEMBL5255 | IC50 | 8.82 | 8.82 | 1.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.013 | mL.min-1.kg-1 | Homo sapiens |
| MRT | 62.0 | hr | Homo sapiens |
| T1/2 | 51.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Toll-like receptor 4 | IC50 | = | 1.5 | nM | 8.82 | Antagonist activity at TLR4 in human serum assessed as reduction in LPS-induced ... | 31188592 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18426954 | 10.1124/dmd.108.020479 | ADMET | 4 |
| 31188592 | 10.1021/acs.jmedchem.8b01732 | Toll-like receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine