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Compound Detail

CHEMBL501843

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O=C1CCCN2[C@@H]3[C@@]45CN6CCCC/C=C\CC[C@@]3(C=C(c3nccc7c3[nH]c3ccccc37)[C@@H]4CC6)O[C@]2(CC1)C5

Basic Information

ChEMBL ID CHEMBL501843
Phase Preclinical
Structure Type MOL
InChI Key XYMOBPPDZDVIQE-IUTPLNCYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
19
Publications
0
Known Names

Molecular Properties

562.8
MW (Da)
6.62
ALogP
5
HBA
1
HBD
61.5
PSA (Ų)
0.34
QED
2
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C36H42N4O2
MW 562.76
Aromatic Rings 3
Heavy Atoms 42
NP-Likeness 1.96

Literature References

PubMed DOI Target Context # Activities
15332848 10.1021/np0400095 Plasmodium falciparum 4
15332848 10.1021/np0400095 Leishmania donovani 3
16872140 10.1021/np0601399 Plasmodium falciparum 2
16872140 10.1021/np0601399 Staphylococcus aureus 2
16872140 10.1021/np0601399 Leishmania donovani 2
15332848 10.1021/np0400095 Staphylococcus aureus 2
15332848 10.1021/np0400095 Mycobacterium intracellulare 1
15332848 10.1021/np0400095 Human immunodeficiency virus 1 1
15332848 10.1021/np0400095 Mycobacterium tuberculosis 1
16872140 10.1021/np0601399 Mycobacterium tuberculosis 1
15332848 10.1021/np0400095 Cryptococcus neoformans 1
15332848 10.1021/np0400095 Vero 1
16872140 10.1021/np0601399 Cryptococcus neoformans 1
16872140 10.1021/np0601399 Mycobacterium intracellulare 1
16872140 10.1021/np0601399 Human immunodeficiency virus 1 1
16872140 10.1021/np0601399 Vero 1
16872140 10.1021/np0601399 Acetylcholinesterase 1
16872140 10.1021/np0601399 Beta-secretase 1 1
23665143 10.1016/j.bmc.2013.04.025 NON-PROTEIN TARGET 1

Data from ChEMBL 36 via Core Engine