Compound Detail
CHEMBL504
DIMETHYL SULFOXIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL504 |
| Name | DIMETHYL SULFOXIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IAZDPXIOMUYVGZ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
22
Activities
3
Assay Types
0
PK Parameters
20
Publications
11
Known Names
14
Indications
1
Mechanisms
Molecular Properties
78.1
MW (Da)
-0.01
ALogP
1
HBA
0
HBD
23.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1978 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Arthralgia Cystitis Infections Myalgia Reflex, Abnormal Urinary Bladder, Overactive Urinary Incontinence Urinary Incontinence, Urge Contracture Cystitis, Interstitial HIV Infections Melanoma Neoplasms Osteoarthritis
ATC Classification
G04BX13
dimethyl sulfoxide
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: UROLOGICALS
M02AX03
dimethyl sulfoxide
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Activity Summary
IC50 9 meas. best 4.68
Kd 7 meas.
Ki 6 meas. best 4.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cereblon isoform 4 CHEMBL3763007 | Ki | 4.97 | 4.97 | 10700.0 | 1 |
| Cereblon isoform 4 CHEMBL3763007 | IC50 | 4.68 | 4.68 | 20800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cereblon isoform 4 | Ki | = | 10700.0 | nM | 4.97 | Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measu... | 33488967 |
| Cereblon isoform 4 | IC50 | = | 20800.0 | nM | 4.68 | Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measu... | 33488967 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15713399 | 10.1016/j.bmcl.2005.01.002 | Trypanosoma cruzi | 12 |
| - | 10.6019/CHEMBL4295262 | Unchecked | 12 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 9 |
| 3806621 | 10.1021/jm00385a025 | HL-60 | 9 |
| 21138784 | 10.1016/j.ejmech.2010.11.009 | NCI-H460 | 8 |
| - | 10.6019/CHEMBL5058564 | U2OS | 7 |
| 12477349 | 10.1021/jm0208828 | Insulin-like growth factor-binding protein 5 | 7 |
| 6793727 | 10.1021/jm00141a015 | Friend leukemia cell line | 6 |
| 3531516 | 10.1021/jm00160a001 | Rattus norvegicus | 6 |
| - | 10.6019/CHEMBL5303304 | U2OS | 6 |
| 29416002 | 10.1038/s41419-017-0213-2 | Unchecked | 5 |
| 8057301 | 10.1021/jm00042a011 | Mus musculus | 5 |
| - | 10.6019/CHEMBL5058564 | Fibroblast | 5 |
| 33488967 | 10.1021/acsmedchemlett.0c00440 | Cereblon isoform 4 | 4 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 4 |
| 281531 | 10.1021/jm00207a007 | Unchecked | 4 |
| 12036364 | 10.1021/jm010365+ | Unchecked | 3 |
| 27108400 | 10.1016/j.bmc.2016.04.016 | NON-PROTEIN TARGET | 3 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 33488967 | 10.1021/acsmedchemlett.0c00440 | Protein cereblon | 3 |
Data from ChEMBL 36 via Core Engine