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Compound Detail

CHEMBL504964

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N=C(N)NCCC[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O

Basic Information

ChEMBL ID CHEMBL504964
Phase Preclinical
Structure Type MOL
InChI Key ROTHBSFMHAHRTG-ZOHVZMGWSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

894.0
MW (Da)
0.42
ALogP
11
HBA
11
HBD
338.1
PSA (Ų)
0.03
QED
3
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C42H47N13O8S
MW 893.99
Aromatic Rings 5
Heavy Atoms 64

Literature References

PubMed DOI Target Context # Activities
18412316 10.1021/jm701181n Melanocortin receptor 4 3
18412316 10.1021/jm701181n Melanocortin receptor 3 3
18412316 10.1021/jm701181n Melanocortin receptor 5 3
18412316 10.1021/jm701181n Melanocyte-stimulating hormone receptor 3

Data from ChEMBL 36 via Core Engine