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Compound Detail

CHEMBL506838

ACETYL PODOCARPIC ACID ANHYDRIDE
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CC(=O)Oc1ccc2c(c1)[C@@]1(C)CCC[C@](C)(C(=O)OC(=O)[C@@]3(C)CCC[C@]4(C)c5cc(OC(C)=O)ccc5CC[C@@H]34)[C@@H]1CC2

Basic Information

ChEMBL ID CHEMBL506838
Name ACETYL PODOCARPIC ACID ANHYDRIDE
Phase Preclinical
Structure Type MOL
InChI Key OUJQRQRBNRGQTC-SPGSYPTKSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

614.8
MW (Da)
7.33
ALogP
7
HBA
0
HBD
96.0
PSA (Ų)
0.20
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C38H46O7
MW 614.78
Aromatic Rings 2
Heavy Atoms 45
NP-Likeness 0.97

Activity Summary

EC50 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxysterols receptor LXR-alpha
CHEMBL2808
EC50 9.0 9.0 1.0 2
Oxysterols receptor LXR-beta
CHEMBL4093
EC50 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL5303304 U2OS 9
- 10.6019/CHEMBL5303304 HEK-293T 7
- 10.6019/CHEMBL5303304 Fibroblast 7
- 10.6019/CHEMBL5724696 TERT-RPE1 4
16124770 10.1021/np050182g Oxysterols receptor LXR-beta 3
16124770 10.1021/np050182g Oxysterols receptor LXR-alpha 3
- 10.6019/CHEMBL5308504 Casein kinase I isoform delta 1
- 10.6019/CHEMBL5308504 Cyclin-dependent kinase 2 1
- 10.6019/CHEMBL5308504 Glycogen synthase kinase-3 beta 1
- 10.6019/CHEMBL5308504 Mitogen-activated protein kinase 1 1
- 10.6019/CHEMBL5308504 Aurora kinase A 1
- 10.6019/CHEMBL5308504 Tyrosine-protein kinase ABL1 1
- 10.6019/CHEMBL5308504 Fibroblast growth factor receptor 3 1
- 10.6019/CHEMBL5308504 Peregrin 1
- 10.6019/CHEMBL5308504 Transcription intermediary factor 1-alpha 1
- 10.6019/CHEMBL5308504 Bromodomain-containing protein 4 1
- 10.6019/CHEMBL5715260 Hepatocyte nuclear factor 4-alpha 1
- 10.6019/CHEMBL5715260 Retinoic acid receptor RXR-alpha 1
- 10.6019/CHEMBL5715260 Nuclear receptor subfamily 2 group C member 1 1
- 10.6019/CHEMBL5715260 Nuclear receptor subfamily 2 group E member 1 1

Data from ChEMBL 36 via Core Engine