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Compound Detail

CHEMBL5079289

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CCN1CCN(CCCn2cnc3c(N4CCN(CC)CC4)nc(N)nc32)CC1

Basic Information

ChEMBL ID CHEMBL5079289
Phase Preclinical
Structure Type MOL
InChI Key WMFBRECXBGCIEB-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

401.6
MW (Da)
0.58
ALogP
9
HBA
1
HBD
82.6
PSA (Ų)
0.72
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H35N9
MW 401.56
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -1.31

Activity Summary

IC50 2 meas. best 6.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 9
CHEMBL5804
IC50 6.58 6.58 260.0 1
Toll-like receptor 7
CHEMBL5936
IC50 4.79 4.79 16220.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34142551 10.1021/acs.jmedchem.1c00532 Toll-like receptor 9 1
34142551 10.1021/acs.jmedchem.1c00532 Toll-like receptor 7 1

Data from ChEMBL 36 via Core Engine