Compound Detail
CHEMBL5081206
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Basic Information
| ChEMBL ID | CHEMBL5081206 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MIKZQMWNBSDPDJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
396.4
MW (Da)
1.69
ALogP
7
HBA
1
HBD
85.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA-directed RNA polymerase I subunit RPA1 CHEMBL3286067 | IC50 | 5.16 | 5.16 | 6860.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA-directed RNA polymerase I subunit RPA1 | IC50 | = | 6860.0 | nM | 5.16 | Inhibition of RNA polymerase 1 in human A-375 assessed as RPA194 degradation mea... | 35450366 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35450366 | 10.1021/acsmedchemlett.1c00660 | DNA-directed RNA polymerase I subunit RPA1 | 1 |
Data from ChEMBL 36 via Core Engine