Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5089259

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCN1CCN(CCCn2cnc3c(N4CCN(CC)CC4)nc(NCc4ccc(OC)cc4)nc32)CC1

Basic Information

ChEMBL ID CHEMBL5089259
Phase Preclinical
Structure Type MOL
InChI Key ROGYDRPJFOGJNC-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

521.7
MW (Da)
2.62
ALogP
10
HBA
1
HBD
77.8
PSA (Ų)
0.41
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H43N9O
MW 521.71
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -1.28

Activity Summary

IC50 2 meas. best 6.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 9
CHEMBL5804
IC50 6.7 6.7 200.0 1
Toll-like receptor 7
CHEMBL5936
IC50 5.28 5.28 5220.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34142551 10.1021/acs.jmedchem.1c00532 Toll-like receptor 9 1
34142551 10.1021/acs.jmedchem.1c00532 Toll-like receptor 7 1

Data from ChEMBL 36 via Core Engine