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Compound Detail

CHEMBL5089479

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COc1cscc1-c1cn(C2CCC(=O)NC2=O)nn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5089479
Phase Preclinical
Structure Type MOL
InChI Key SKUSCUALKIOIST-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

292.3
MW (Da)
0.99
ALogP
7
HBA
1
HBD
86.1
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H12N4O3S
MW 292.32
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness -0.88

Literature References

PubMed DOI Target Context # Activities
34965125 10.1021/acs.jmedchem.1c01832 Protein cereblon/Phosphodiesterase 6D 4
34965125 10.1021/acs.jmedchem.1c01832 Protein cereblon/Aiolos 2
34965125 10.1021/acs.jmedchem.1c01832 Cereblon/Ikaros 2
34965125 10.1021/acs.jmedchem.1c01832 Cereblon/Casein kinase I alpha 2
34965125 10.1021/acs.jmedchem.1c01832 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 1
34965125 10.1021/acs.jmedchem.1c01832 MIA PaCa-2 1
34965125 10.1021/acs.jmedchem.1c01832 AGS 1
34965125 10.1021/acs.jmedchem.1c01832 NCI-H358 1
34965125 10.1021/acs.jmedchem.1c01832 PaTu 8988t 1
34965125 10.1021/acs.jmedchem.1c01832 DNA-binding protein Ikaros 1

Data from ChEMBL 36 via Core Engine