Compound Detail

CHEMBL5095401

IPTACOPAN HYDROCHLORIDE

💊 Approved Drug

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💊 Approved Drug

CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1.Cl.O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5095401
Name	IPTACOPAN HYDROCHLORIDE
Phase	Approved
Structure Type	MOL
InChI Key	JUWBBUFSAGEROP-VVJLZRNGSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL4594448
Active Moiety	CHEMBL4594448

Known Names

Fabhalta Iptacopan hydrochloride Iptacopan hydrochloride monohydrate LNP-023 HYDROCHLORIDE MONOHYDRATE LNP-023-AAB LNP023-AAB NVP-LNP023-AAB

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

422.5

MW (Da)

4.93

ALogP

HBA

HBD

74.8

PSA (Å²)

0.56

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	2023
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Oral

Flags

Black Box Warning First in Class

USAN Stem	-copan
USAN Year	2021

Extended Properties

Molecular Formula	C25H33ClN2O5
MW	477.00
Aromatic Rings	3
Heavy Atoms	31
NP-Likeness	-0.20

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Complement factor B inhibitor	INHIBITOR	Complement factor B	✓	✓

Indications

Glomerulonephritis, IGA Hemoglobinuria, Paroxysmal Hemoglobinuria, Paroxysmal Glomerulonephritis Kidney Diseases

Drug Warnings

Black Box Warning

General Warning

Country: United States

Data from ChEMBL 36 via Core Engine