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Compound Detail

CHEMBL509924

DIFLUCORTOLONE
🧪 Phase II
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🧪 Phase II
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL509924
Name DIFLUCORTOLONE
Phase Phase II
Structure Type MOL
InChI Key OGPWIDANBSLJPC-RFPWEZLHSA-N
Therapeutic ✓ Yes

Known Names

BAY-866146 BAY866146 Diflucortolona Diflucortolone Diflucortolone 21-valerate Diflucortolone valerate Nerisone Nerisone fte Temetex
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
9
Known Names
1
Mechanisms

Molecular Properties

394.5
MW (Da)
2.73
ALogP
4
HBA
2
HBD
74.6
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -cort-; -olone
USAN Year 1967

Extended Properties

Molecular Formula C22H28F2O4
MW 394.46
Aromatic Rings 0
Heavy Atoms 28
NP-Likeness 1.97

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Unknown - - ✓ ✓

ATC Classification

D07AC06
diflucortolone
Level 1: DERMATOLOGICALS
Level 2: CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07XC04
diflucortolone
Level 1: DERMATOLOGICALS
Level 2: CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
20185316 10.1016/j.bmc.2010.01.068 Cryptosporidium parvum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania amazonensis 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania donovani 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
37468498 10.1038/s41467-023-40064-9 Androgen receptor 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trichomonas vaginalis 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei rhodesiense 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1

Data from ChEMBL 36 via Core Engine