Compound Detail
CHEMBL511352
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Basic Information
| ChEMBL ID | CHEMBL511352 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JMIBSVABGHKOBI-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
340.4
MW (Da)
3.60
ALogP
5
HBA
0
HBD
60.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 CHEMBL3772 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Metabotropic glutamate receptor 1 CHEMBL2892 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| Metabotropic glutamate receptor 5 CHEMBL3227 | IC50 | 6.06 | 6.06 | 880.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | IC50 | = | 11.0 | nM | 7.96 | Antagonist activity at human mGluR1 expressed in CHO cells assessed as calcium f... | 18849168 |
| Metabotropic glutamate receptor 1 | IC50 | = | 58.0 | nM | 7.24 | Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium f... | 18849168 |
| Metabotropic glutamate receptor 5 | IC50 | = | 880.0 | nM | 6.06 | Antagonist activity at human mGluR5 expressed in CHO cells assessed as calcium f... | 18849168 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18849168 | 10.1016/j.bmc.2008.09.060 | Metabotropic glutamate receptor 1 | 2 |
| 18849168 | 10.1016/j.bmc.2008.09.060 | No relevant target | 1 |
| 18849168 | 10.1016/j.bmc.2008.09.060 | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine