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Compound Detail

CHEMBL51442

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CCCCCCCCSCc1c(O)c(CSCCCCCCCC)c2c(c1O)[C@H](SCCCCCCCC)[C@@H](OC(=O)c1cc(O)c(O)c(O)c1)[C@@H](c1cc(O)c(O)c(O)c1)O2

Basic Information

ChEMBL ID CHEMBL51442
Phase Preclinical
Structure Type MOL
InChI Key AINKEUDWUIKIDJ-TYWMPALESA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

919.3
MW (Da)
13.01
ALogP
14
HBA
8
HBD
197.4
PSA (Ų)
0.02
QED
4
Ro5 Violations
29
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H70O11S3
MW 919.28
Aromatic Rings 3
Heavy Atoms 62
NP-Likeness 0.60

Activity Summary

IC50 2 meas. best 4.71

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.71 4.71 19400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 19400.0 nM 4.71 Inhibitory activity against lipid peroxidation of egg-phosphatidylcholine (PC) l... 9873437

Literature References

PubMed DOI Target Context # Activities
9873437 10.1016/s0960-894x(98)00311-4 Unchecked 2
9873437 10.1016/s0960-894x(98)00311-4 No relevant target 1

Data from ChEMBL 36 via Core Engine