Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL514721

FLUOROSALINOSPORAMIDE
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C[C@@]12OC(=O)[C@]1([C@@H](O)[C@@H]1C=CCCC1)NC(=O)[C@@H]2CCF
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL514721
Name FLUOROSALINOSPORAMIDE
Phase Preclinical
Structure Type MOL
InChI Key BBRUKBOXDSBEQC-SHTIJGAHSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names

Molecular Properties

297.3
MW (Da)
0.86
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H20FNO4
MW 297.33
Aromatic Rings 0
Heavy Atoms 21
NP-Likeness 2.55

Activity Summary

IC50 1 meas. best 8.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 8.04 8.04 9.2 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 1.317 hr -

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 9.2 nM 8.04 Inhibition of chymotrypsin-like activity of rabbit 20S proteasome 18939815

Literature References

PubMed DOI Target Context # Activities
18939815 10.1021/jm800548b Unchecked 4
18939815 10.1021/jm800548b No relevant target 1

Data from ChEMBL 36 via Core Engine