Compound Detail
CHEMBL515763
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL515763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WDPUHMPVZBSBGB-LICLKQGHSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
278.3
MW (Da)
3.09
ALogP
5
HBA
2
HBD
70.4
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 5.77 | 5.77 | 1700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 1700.0 | nM | 5.77 | Activation of human mGluR4 expressed in CHO cells coexpressing Gqi5 protein asse... | 19097893 |
| Metabotropic glutamate receptor 4 | EC50 | = | 1700.0 | nM | 5.77 | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells as... | 21688779 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 4 | 4 |
| 21688779 | 10.1021/jm200290z | Metabotropic glutamate receptor 4 | 2 |
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 1 | 1 |
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 2 | 1 |
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 5 | 1 |
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 7 | 1 |
| 19097893 | 10.1016/j.bmcl.2008.11.104 | Metabotropic glutamate receptor 8 | 1 |
Data from ChEMBL 36 via Core Engine