Compound Detail
CHEMBL5169928
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N#Cc1cccc(-c2cncc(-c3nc4c(F)cccc4[nH]3)c2N2C[C@@H](N)[C@H](F)C2)c1
Basic Information
| ChEMBL ID | CHEMBL5169928 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WBNMUAMVUMUFII-RTBURBONSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
416.4
MW (Da)
3.79
ALogP
5
HBA
2
HBD
94.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 5 CHEMBL1792 | EC50 | 8.3 | 8.29 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 5 | EC50 | = | 5.012 | nM | 8.3 | Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction i... | 35605837 |
| Somatostatin receptor type 5 | EC50 | = | 5.2 | nM | 8.28 | Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction i... | 35605837 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35605837 | 10.1016/j.bmcl.2022.128807 | Somatostatin receptor type 5 | 2 |
Data from ChEMBL 36 via Core Engine