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Compound Detail

CHEMBL517199

XIPAMIDE
🧪 Phase II
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🧪 Phase II
Cc1cccc(C)c1NC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL517199
Name XIPAMIDE
Phase Phase II
Structure Type MOL
InChI Key MTZBBNMLMNBNJL-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

BE-1293 Diurexan MJF 10,938 MJF-10938 Xipamida Xipamide
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
6
Known Names
1
Indications

Molecular Properties

354.8
MW (Da)
2.56
ALogP
4
HBA
3
HBD
109.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Stem -pamide
USAN Year 1976

Extended Properties

Molecular Formula C15H15ClN2O4S
MW 354.81
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -1.52

Indications

Cardiovascular Diseases

ATC Classification

C03BA10
xipamide
Level 1: CARDIOVASCULAR SYSTEM
Level 2: DIURETICS

Literature References

PubMed DOI Target Context # Activities
20014752 10.1021/tx900326k Hepatotoxicity 3
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Entamoeba histolytica 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania donovani 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania infantum 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania major 1
20185316 10.1016/j.bmc.2010.01.068 Leishmania mexicana 1
18834112 10.1021/jm800656v Amine oxidase [flavin-containing] A 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 Trichomonas vaginalis 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei rhodesiense 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1

Data from ChEMBL 36 via Core Engine