Compound Detail
CHEMBL5177351
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Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1
Basic Information
| ChEMBL ID | CHEMBL5177351 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SLPWRCRRHVRNRM-DQHNISQXSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1016.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 CHEMBL4296140 | EC50 | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 | EC50 | = | 13.0 | nM | 7.89 | PROTAC activity at VHL/BRD4 in human MCF7 cells assessed as BRD4 degradation mea... | 35916496 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35916496 | 10.1021/acs.jmedchem.2c00875 | von Hippel-Lindau disease tumor suppressor/Bromodomain-containing protein 4 | 2 |
| 35916496 | 10.1021/acs.jmedchem.2c00875 | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine