Compound Detail
CHEMBL5177614
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(CO)c4)c3n2)C1
Basic Information
| ChEMBL ID | CHEMBL5177614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | URDSPGFWWLEKBJ-QKFKETGDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
557.5
MW (Da)
3.61
ALogP
10
HBA
3
HBD
130.7
PSA (Ų)
0.33
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 CHEMBL5358 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 | IC50 | = | 91.0 | nM | 7.04 | Inhibition of GCN2 (unknown origin) | 36127295 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36127295 | 10.1021/acs.jmedchem.2c00736 | eIF-2-alpha kinase GCN2 | 2 |
Data from ChEMBL 36 via Core Engine