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Compound Detail

CHEMBL517927

TOMENTODIPLACONE B
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COc1cc([C@@H]2CC(=O)c3c(cc(O)c(C/C=C(\C)C/C=C/C(C)(C)O)c3O)O2)ccc1O

Basic Information

ChEMBL ID CHEMBL517927
Name TOMENTODIPLACONE B
Phase Preclinical
Structure Type MOL
InChI Key SHWLJHMWQFNVAC-DETBAYCCSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
19
Publications
0
Known Names

Molecular Properties

454.5
MW (Da)
4.72
ALogP
7
HBA
4
HBD
116.5
PSA (Ų)
0.45
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H30O7
MW 454.52
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness 2.37

Literature References

PubMed DOI Target Context # Activities
25735399 10.1021/acs.jnatprod.5b00005 THP-1 2
18293924 10.1021/np070446u Staphylococcus epidermidis 1
25735399 10.1021/acs.jnatprod.5b00005 NON-PROTEIN TARGET 1
20192247 10.1021/np900681y THP-1 1
20192247 10.1021/np900681y BJ 1
20192247 10.1021/np900681y HeLa 1
20192247 10.1021/np900681y U-266 1
20192247 10.1021/np900681y RPMI-8226 1
20192247 10.1021/np900681y CCRF-CEM 1
20192247 10.1021/np900681y MCF7 1
18293924 10.1021/np070446u Escherichia coli 1
18293924 10.1021/np070446u Staphylococcus aureus 1
18293924 10.1021/np070446u Listeria monocytogenes 1
18293924 10.1021/np070446u Enterococcus faecalis 1
18293924 10.1021/np070446u Bacillus subtilis 1
18293924 10.1021/np070446u Bacillus cereus 1
18293924 10.1021/np070446u Candida albicans 1
18293924 10.1021/np070446u Salmonella enteritidis 1
18293924 10.1021/np070446u Pseudomonas aeruginosa 1

Data from ChEMBL 36 via Core Engine