Compound Detail
CHEMBL5179548
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Basic Information
| ChEMBL ID | CHEMBL5179548 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GRDLXXJSRHDATN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
163.2
MW (Da)
0.40
ALogP
5
HBA
1
HBD
55.6
PSA (Ų)
0.66
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 3.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| YTH domain-containing protein 1 CHEMBL5169187 | IC50 | 3.51 | 3.51 | 306000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| YTH domain-containing protein 1 | IC50 | = | 306000.0 | nM | 3.51 | Binding affinity to GST-tagged YTHDC1 m6A-reader domain (unknown origin) using R... | 36110386 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36110386 | 10.1021/acsmedchemlett.2c00303 | YTH domain-containing protein 1 | 2 |
| 36110386 | 10.1021/acsmedchemlett.2c00303 | YTH domain-containing family protein 2 | 1 |
| 38787793 | 10.1021/acs.jmedchem.4c00599 | YTH domain-containing protein 1 | 1 |
Data from ChEMBL 36 via Core Engine