Compound Detail
CHEMBL5184847
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Basic Information
| ChEMBL ID | CHEMBL5184847 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CBUBUEVQMMYUGL-WAVHTBQISA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
321.3
MW (Da)
2.35
ALogP
5
HBA
4
HBD
111.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 8.1 | 7.1 | 7.9 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 7.89 | nM | 8.1 | Inhibition of FLT3 (unknown origin) | 34161865 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 8.0 | nM | 8.1 | In Vitro Kinase Assay: The inhibition of the FLT3 kinase activity was measured w... | - |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 7890.0 | nM | 5.1 | Inhibition of recombinant FLT3 (unknown origin) by HTRF assay | 34161865 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34161865 | 10.1016/j.ejmech.2021.113652 | Receptor-type tyrosine-protein kinase FLT3 | 2 |
| 34161865 | 10.1016/j.ejmech.2021.113652 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine