Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5187131

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCn1nc(C)cc1C(=O)NCCCOc1cc(C(N)=O)cc2nc(NC(=O)c3cc(C)nn3CC)n(C/C=C/Cn3c(NC(=O)c4cc(C)nn4CC)nc4cc(C(N)=O)cc(OC)c43)c12

Basic Information

ChEMBL ID CHEMBL5187131
Phase Preclinical
Structure Type MOL
InChI Key SPGORUIXYNTYKM-VAWYXSNFSA-N
0
Targets
1
Activities
1
Assay Types
4
PK Parameters
5
Publications
0
Known Names

Molecular Properties

916.0
MW (Da)
4.13
ALogP
17
HBA
5
HBD
281.0
PSA (Ų)
0.05
QED
2
Ro5 Violations
20
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C45H53N15O7
MW 916.02
Aromatic Rings 7
Heavy Atoms 67
NP-Likeness -0.77

Activity Summary

EC50 1 meas.

Pharmacokinetic Data

Parameter Value Units Species
AUC 4240.0 ng.hr.mL-1 Mus musculus
AUC 4300.0 ng.hr.mL-1 Mus musculus
CL 12.0 mL.min-1.kg-1 Mus musculus
T1/2 1.75 hr Mus musculus

Literature References

PubMed DOI Target Context # Activities
35315650 10.1021/acs.jmedchem.1c01795 Unchecked 8
35315650 10.1021/acs.jmedchem.1c01795 ADMET 7
35315650 10.1021/acs.jmedchem.1c01795 CT26 3
35315650 10.1021/acs.jmedchem.1c01795 Stimulator of interferon genes protein 2
35315650 10.1021/acs.jmedchem.1c01795 Nuclear factor NF-kappa-B complex 1

Data from ChEMBL 36 via Core Engine